European and Arab leaders are to hold a summit on Sunday (today) at Red Sea resort of Sharm El Sheikh in Egypt.
The diplomats from both sides see a chance to boost cooperation across the troubled Mediterranean region and find solutions to the conflicts.
Egyptian President Abdel Fattah Al Sisi will host the two-day summit.
Arab countries are grappling with the fallout from Arab Spring revolutions.
Wars and conflicts in places such as Syria and Libya are on the agenda at a summit.
The leaders will also discuss topics like trade, development, security, and migration.
Analysts voiced doubts that how progress can be made with Europe split over migration and backing various parties.
European leaders first mentioned the summit in Austria in September amid efforts to agree ways to curb the illegal migration.
The illegal migration has sharply divided the 28-nation European bloc.
The European Union Foreign Policy Chief Federica Mogherini said that the Egypt summit is more than meeting of 40 heads of states and governments.
She said, discussions will be held on economic co-operation, adding, this is a troubled region but also full of opportunities.
President of the European Council of EU member countries Donald Tusk, European Commission President Jean-Claude Juncker, German Chancellor Angela Merkel, British Prime Minister Theresa May, Irish Prime Minister Leo Varadkar, Lebanese Prime Minister Saad Hariri, Tunisian President Beji Caid Essebsi, Iraqi president Barham Salih and other Arab leaders will attend the summit.
Former EU ambassador to Tunisia and Libya, Marc Pierini, said the summit will struggle to establish a dialogue between two sides who are confronted with their own challenges.